End Stage Renal Disease (ESRD)
What are the Options Once Kidney Failure is Advanced End-Stage Renal Disease?
It is time to make plans for renal replacement therapy (dialysis, transplant) when kidney function falls to 20% of normal. HUS patients need renal replacement therapy to survive if kidney function drops to less than 10 % of normal. In children who are not thriving, renal replacement therapy is usually required before kidney function drops this low.
The point at which kidney replacement therapy is needed for survival is called end-stage renal disease (ESRD) or Stage 5 chronic kidney disease. Assuming that HUS patients have been followed, evaluated and treated as described above, they may be healthy enough to receive a pre-emptive transplant, that is, without first requiring dialysis. This usually requires that a living related kidney donor (usually a parent or sibling) is available.