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Risk factors for the development of Escherichia coli O157:H7 associated with HUS

Risk factors for the development of Escherichia coli O157:H7 associated with hemolytic uremic syndrome. Kawamura N, Yamazaki T, Tamai H. Pediatrics International 1999;41:218-222.

ABSTRACT:

This study investigated the risk factors that may contribute to the development of HUS in the early stages of infection with Escherichia coli O157:H7. Pediatric patients diagnosed with O157:H7 infection during the mass outbreak in Sakai, Osaka, Japan in 1996 were included in this study. Leukocyte counts and C-reactive protein levels at the first examination were significantly higher in the group that developed HUS than those in the non-HUS group. Serum sodium concentration in the HUS group was lower. There were no significant differences between the two groups for other laboratory tests. There were also no significant differences between the two groups with respect to sex, age, rates of clinical manifestations, or the use of anti-diarrheal agents, antimotility agents, and/or antibiotic agents. These findings suggest that patients with laboratory findings suggesting high levels of inflammation should be carefully managed as early as possible.